Iron biofortification: a much-needed strategy for prevailing conditions of micronutrient malnutrition

Authors

  • Zain Mushtaq Department of Soil Science, University of the Punjab, Lahore
  • Anum Nazir Department of Nutrition and Dietetics, The University of Faisalabad
  • Muhammad Tauseef Jaffar College of Natural Resources and Environment, Northwest A&F University, Yangling

DOI:

https://doi.org/10.6092/issn.2281-4485/17111

Keywords:

Micronutrient, malnutrition, biofortification, human health

Abstract

Micronutrient-malnutrition is one of the most serious battle human beings are fighting. The so-called Hidden hunger is all because of micronutrient deficiencies. Iron deficiency anemia is affecting more people than any other prevailing disorder. However, iron-supplementation aggravate the infectious diseases and present policies of iron therapy carefully evaluate the pros and cons. In current review, we have evaluated the biofortification approaches for combating hidden hunger, in the light of medical and nutritional advancements. Enhancement of iron in edible plant parts is expected to improve nutrient status of human beings via crops. The density of minerals and vitamins in staple foods consumed by the poor can be raised using either traditional plant breeding or transgenic approaches, a process known as biofortification. Microbial iron biofortification is a valuable approach for human being especially in developing countries where poor people cannot afford to buy expensive supplementation. Moreover, prevailing condition of Covid-19 demands a fighting immune system and iron is likely to play vital role in improving human immune system.

References

BOUIS H.E., WELCH R.M. (2010) Biofortification—a sustainable agricultural strategy for reducing micronutrient malnutrition in the global south. Crop science, 50: S-20. Doi: https://doi.org/10.2135/cropsci2009.09.0531

COEY J.M.D., SUN H. (1990) Improved magnetic properties by treatment of iron-based rare earth intermetallic compounds in anmonia. Journal of Magnetism and magnetic materials, 87(3): L251-L254. https://doi.org/10.1016/0304-8853(90)90756-G

FROSSARD E., BUCHER M., MÄCHLER F., MOZAFAR A., HURRELL R. (2000) Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition. Journal of the Science of Food and Agriculture, 80(7):861-879. https://doi.org/10.1002/(SICI)1097-0010(20000515)80:7%3C861:AID-JSFA601%3E3.0.CO;2-P

GÖDECKE T., STEIN A.J., QAIM M. (2018) The global burden of chronic and hidden hunger: trends and determinants. Global food security, 17: 21-29. https://doi.org/10.1016/j.gfs.2018.03.004

GROMOVA O.A., TORSHIN I.Y., SHAPOVALOVA Y.O., KURTSER M.A., CHUCHALIN A.G. (2020) COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy. Obstetrics, Gynecology and Reproduction, 14(5):644-55.: https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.179

HARDING K.L., AGUAYO,V.M., WEBB P. (2018) Hidden hunger in South Asia: a review of recent trends and persistent challenges. Public health nutrition, 21(4):785-795. https://doi.org/10.1017/S1368980017003202

LATA-TENESACA L.F., DE MELLO PRADO R., AJILA-CELI G.E., DA SILVA D.L., JUNIOR J.S.P., MATTIUZ B.H. (2023) Iron biofortification in quinoa: Effect of iron application methods on nutritional quality, anti-nutrient composition, and grain productivity. Food Chemistry, 404:134573.

MAYER J.E., PFEIFFER W.H., BEYER P. (2008( Biofortified crops to alleviate micronutrient malnutrition. Current opinion in plant biology, 11(2):166-170. https://doi.org/10.1016/j.pbi.2008.01.007.

MESQUITA G., SILVA T., GOMES A.C., OLIVEIRA P.F., ALVES M.G., FERNANDES R., ALMEIDA A.A., MOREIRA A.C., GOMES M.S. (2020) H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron. Scientific reports, 10(1): 1-15. https://doi.org/10.1038/s41598-020-59898-0

MURGIA I., AROSIO P., TARANTINO D., SOAVE C. (2012) Biofortification for combating ‘hidden hunger’for iron. Trends in plant science, 17(1):47-55. https://doi.org/10.1016/j.tplants.2011.10.003

MUSHTAQ Z., NAZIR A. (2021) Biofortification: way forward toward micronutrient deficiency: Biofortification a sustainable approach. EQA-International Journal of Environmental Quality, 42:36-41. https://doi.org/10.6092/issn.2281-4485/11598

NAITO Y., MASUYAMA T., ISHIHARA M. (2021) Iron and cardiovascular diseases. Journal of Cardiology, 77(2):160-165. https://doi.org/10.1016/j.jjcc.2020.07.009

NEFF L.M. (2020) Hidden hunger: food insecurity in the age of coronavirus. The American journal of clinical nutrition, 12(5):1160-1161. https://doi.org/10.1093/ajcn/nqaa279

REHMAN H.M., COOPER J.W., LAM H.M., YANG S.H. (2019) Legume biofortification is an nderexploited strategy for combatting hidden hunger. Plant, cell & environment, 42(1): 52-70. https://doi.org/10.1111/pce.13368

SALDANHA L., DWYER J., BROWN L., ANDREWS K., GUSEV P., PEHRSSON P. (2017) The iron paradox: discrepancies in iron chemical forms found in prenatal supplements and tested in clinical trials. The FASEB Journal, 31: 647-4. https://doi.org/10.1096/fasebj.31.1_supplement.647.4

SAWICKA K., HALE C.R., PARK C.Y., FAK J.J., GRESACK J.E., VAN DRIESCHE S.J., KANG J.J., DARNELL J.C., DARNELL R.B. (2019) FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory. Elife, 8, p.e46919. https://doi.org/10.7554/eLife.46919

SHUBHAM K., ANUKIRUTHIKA T., DUTTA S., KASHYAP A.V., MOSES J.A., NDHARAMAKRISHNAN C. (2020) Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches. Trends in Food Science & Technology, 99:58-75. https://doi.org/10.1016/j.tifs.2020.02.021

THOMPSON B. (2007) Food-based approaches for combating iron deficiency. Nutritional anemia, 337:1-21. https://doi.org/10.1096/fasebj.31.1_supplement.647.4

VÉLEZ-BERMÚDEZ I.C., SCHMIDT W. (2023) Plant strategies to mine iron from alkaline substrates. Plant and Soil, 483(1-2), pp.1-25. https://doi.org/10.1007/s11104-022-05746-1

VELU G., ORTIZ-MONASTERIO I., CAKMAK I., HAO Y., SINGH R.Á. (2014) Biofortification strategies to increase grain zinc and iron concentrations in wheat. Journal of cereal science, 59(3):365-372. https://doi.org/10.1016/j.jcs.2013.09.001

VIETH J.T., LANE D.R. (2014) Anemia. Emergency Medicine Clinics. 1:32(3):613-28. https://doi.org/10.1016/j.emc.2014.04.007

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Published

2023-08-24

How to Cite

Mushtaq, Z., Nazir, A., & Jaffar, M. T. (2023). Iron biofortification: a much-needed strategy for prevailing conditions of micronutrient malnutrition. EQA - International Journal of Environmental Quality, 57(1), 24–28. https://doi.org/10.6092/issn.2281-4485/17111

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Articles