Land use indicators and causes of death patterns in South America: a correlation, PCA and regression analysis
DOI:
https://doi.org/10.60923/issn.2281-4485/23264Keywords:
Land use and land cover change, causes of death, correlations, principal component analysis, linear regressionAbstract
This study explores the link between land use and land cover change (LUCC) and causes of death (CD) in South America from 1990 to 2021. Key LUCC indicators (agricultural land, arable land, hectares per person, and forest area) were analyzed using correlation, principal component analysis (PCA), and linear regression. Findings show that reduced LUCC indicators correlate with higher mortality from cancers, particularly skin melanoma, colon, and pancreatic cancers. PCA revealed that declines in LUCC contribute to environmental pollution and increased cancer risks. Temporal trends showed rising rates of colon cancer and stroke, while leukemia declined. Environmental factors such as pesticide exposure and air pollution were significant contributors. The study emphasizes the need for policies integrating LUCC management with public health strategies to reduce disease risks. Limitations include regional focus and lack of age-specific data, suggesting future research should focus on specific areas and age groups.
References
ALVARADO J., MENESES L., IDROVO-ESPÍN F.M. (2020) Origen probable y transmisión entre especies del SARS-CoV-2. InfoANALÍTICA, 8(2):49–68. https://doi.org/0.26807/ia.v8i2.142
ARÍZALA-QUINTO D., IDROVO-ESPÍN F.M. (2020) Una revisión sobre las variaciones histónicas y la regulación de la expresión génica. InfoANALÍTICA, 8:17–35. https://doi.org/10.26807/ia.v8i1.116
BI F., GAO C., GUO H. (2024) Epigenetic regulation of cardiovascular diseases induced by behavioral and environmental risk factors: Mechanistic, diagnostic, and therapeutic insights. FASEB BioAdvances, 6(11):477–502. https://doi.org/10.1096/fba.2024-00080
BOUMA J. (2010) Implications of the Knowledge Paradox for Soil Science. In: SPARKS D. (Ed.), Advances in Agronomy. Academic Press, London, pp:143–171. https://doi.org/10.1016/S0065-2113(10)06004-9
BRABANT C., GEERINCK A., BEAUDART C., TIRELLI E., GEUZAINE C., BRUYÈRE O. (2022) Exposure to magnetic fields and childhood leukemia: A systematic review and meta-analysis of case-control and cohort studies. Reviews on Environmental Health, 38(2):229–253. https://doi.org/10.1515/reveh-2021-0112
BU Y., ZHANG X., SONG S., SU H., YU Z., GUO Y. (2023) Association of greenspace with hypertension in adults: A systematic review and meta-analysis. International Journal of Environmental Health Research, 34(6):2556–2577. https://doi.org/10.1080/09603123.2023.2259817
CORTÉS-RAMÍREZ S., SHUK-MEI S., LEUNG Y.-K. (2024) Endocrine-disrupting chemicals: A looming threat to current and future generations. International Journal of Molecular Sciences, 25:8222. https://doi.org/10.3390/ijms25158222
DEVI P., MANJULA M., BHAVANI R.V. (2022) Agrochemicals, environment, and human health. Annual Review of Environment and Resources, 47(1):399–421. https://doi.org/10.1146/annurev-environ-120920-111015
GROLEMUND G., WICKHAM H. (2011) Dates and times made easy with lubridate. Journal of Statistical Software, 40(3):1–25. https://doi.org/10.18637/jss.v040.i03
HARTINGER S., YGLESIAS-GONZÁLEZ M., BLAN-CO-VILLAFUERTE L., PALMEIRO-SILVA Y., LESCA-NO A., STEWART-IBARRA A. (2023) The 2022 South America report of The Lancet Countdown on health and climate change: Trust the science. The Lancet Regional Health Americas, 20:100470. https://doi.org/10.1016/j.lana.2023.100470
HE P., LI X., ZOU D. (2025) Environmental factors inducing gastric cancer: Insights into risk and prevention strategies. Discover Oncology, 16:25. https://doi.org/10.1007/s12672-025-01771-5
HU D., ZHU C., AI L., HE T., WANG Y., YE F., YANG L., DING C., ZHU X., LV R., ZHU J., HASSAN B., FENG Y., TAN W., WANG C. (2018) Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats. Emerging Microbes & Infections, 7(1):154. https://doi.org/10.1038/s41426-018-0155-5
INSTITUTE FOR HEALTH METRICS AND EVALUATION (IHME) (2024) Global Burden of Disease Study 2021. Global Burden of Disease Collaborative Network, Seattle, United States. https://vizhub.healthdata.org/gbd-results/
INTERNATIONAL ORGANIZATION FOR STANDAR-DIZATION (ISO). (2016) Occupational health and safety management systems – Requirements with guidance for use (ISO/DIS 45001). ISO, Vernier, Switzerland. http://www.iso.org/iso/catalogue_detail?csnumber=63787
JI X., CHEN J., YE J., XU S., LIN B., HOU K. (2023) Epidemiological analysis of global and regional lung cancer mortality: Based on 30-year data analysis of Global Burden Disease Database. Healthcare, 11(22). https://doi.org/10.3390/healthcare11222920
JOLLIFFE I.T., CADIMA J. (2016) Principal component analysis: A review and recent developments. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 374(2065):20150202. https://doi.org/10.1098/rsta.2015.0202
KAN B., WANG M., JING H., XU H., JIANG X., YAN M., LIANG W., ZHENG H., WAN K., LIU Q., CUI B., XU Y., ZHANG E., WANG H., YE J., LI G., LI M., CUI Z., QI X., CHEN K., XU J. (2005) Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. Journal of Virology, 79(18):11892–11900. https://doi.org/10.1128/JVI.79.18.11892-11900.2005
KARZAI S., ZHANG Z., SUTTON W., PRESCOTT J., SEGEV D., MCADAMS-DEMARCO M., BISWAL S., RAMANATHAN M., MATHUR A. (2022) Ambient particulate matter air pollution is associated with increased risk of papillary thyroid cancer. Surgery, 171(1):212–219. https://doi.org/10.1016/j.surg.2021.05.002
KONDURI S., SINGH M., BOBUSTUC G., ROVIN R., KASSAM A. (2020) Epidemiology of male breast cancer. The Breast, 54:8–14. https://doi.org/10.1016/j.breast.2020.08.010
KOLDE R. (2018) pheatmap: Pretty Heatmaps (R package version 1.0.12). https://github.com/raivokolde/pheatmap
KUMAR V., ABBAS A.K., ASTER J.C. (2017) Patología humana de Robbins. 10th Edition. Elsevier Health Sciences Division, Barcelona.
LA MERRILL M.A., VANDENBERG L.N., SMITH M.T. (2020) Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nature Reviews Endocrinology, 16:45–57. https://doi.org/ 10.1038/s41574-019-0273-8
LEE S., LEE H., KIM H., KOH S. (2020) Incidence, risk factors, and prediction of myocardial infarction and stroke in farmers: A Korean nationwide population-based study. Journal of Preventive Medicine and Public Health, 53(5):313–322. https://doi.org/10.3961/jpmph.20.156
MACKENBACH J. (2021) The rise and fall of diseases: Re-flections on the history of population health in Europe since ca. 1700. European Journal of Epidemiology, 36(12):1199–1205. https://doi.org/ 10.1007/s10654-021-00719-7
MOROS-OCHOA M., CASTRO-NIETO G., QUINTE-RO-ESPAÑOL A., LLORENTE-PORTILLO C. (2022) Forecasting biocapacity and ecological footprint at a worldwide level to 2030 using neural networks. Sustainability, 14:10691. https://doi.org/ 10.3390/su141710691
PAGANO C., NAVARRA G., COPPOLA L., SAVARESE B., AVILIA G., GIARRA A., PAGANO G., MARANO A., TRIFUOGGI M., BIFULCO M. (2023) Impacts of environmental pollution on brain tumorigenesis. International Journal of Molecular Sciences, 24:5045. https://doi.org/ 10.3390/ijms24055045
PAPADAKIS M., MCPHEE S., RABOW M., MCQUAID K., GANDHI M. (2024) Current Medical Diagnosis & Treatment 2024. McGraw Hill, New York.
PESTANA D., TEIXEIRA D., FARIA A., DOMINGUES V., MONTEIRO R., CALHAU C. (2015) Effects of environmental organochlorine pesticides on human breast cancer: Putative involvement on invasive cell ability. Environmental Toxicology, 30:168–176. https://doi.org/ 10.1002/tox.21882
POULSEN A.H., SØRENSEN M., HVIDTFELDT U.A., CHRISTENSEN J.H., BRANDT J., FROHN L.M., KETZEL M., ANDERSEN C., JENSEN S.S., MÜNZEL T., RAASCHOU-NIELSEN O. (2023) Concomitant exposure to air pollution, green space, and noise and risk of stroke: A cohort study from Denmark. The Lancet Regional Health – Europe, 31:100655. https://doi.org/ 10.1016/j.lanepe.2023.100655
QIN Y., WANG D., ZIEGLER A.D., FU B., ZENG Z. (2025) Impact of Amazonian deforestation on precipitation reverses between seasons. Nature, 639:102–108. https//doi.org/10.1038/s41586-024-08570-y
R CORE TEAM. (2023) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/
SABARWAL A., KUMAR K., SINGH R.P. (2018) Hazardous effects of chemical pesticides on human health: Cancer and other associated disorders. Environmental Toxicology and Pharmacology, 63:103–114. https://doi.org/10.1016/j.etap.2018.08.018
SALAZAR A., BALDI G., HIROTA M., SYKTUS J., MCALPINE V. (2021) Land use and land cover change impacts on the regional climate of non-Amazonian South America: A review. Global and Planetary Change, 128:103–119. https://doi.org/ 10.1016/j.gloplacha.2015.02.009
SCHOBER P., BOER C., SCHWARTE L.A. (2018) Correlation coefficients: Appropriate use and interpretation. Anesthesia & Analgesia, 126(5):1763–1768. https://doi.org/ 10.1213/ANE.0000000000002864
SIEVERT C. (2020) Interactive Web-Based Data Visualization with R, plotly, and shiny. Chapman and Hall/CRC, Boca Raton. https://doi.org/ 10.1201/9780429447273
SILVA P., OLIVEIRA V., VASQUES C., DINIZ DOS REIS P., AMATO A. (2021) Exposure to endocrine disruptors and risk of breast cancer: A systematic review. Critical Reviews in Oncology/Hematology, 161:103330. https://doi.org/ 10.1016/j.critrevonc.2021.103330
SORIA S., BUCKBERRY J. (2022) The impact of industrialization on malignant neoplastic disease of bone in England: A study of medieval and industrial samples. International Journal of Paleopathology, 8:32–40. https://doi.org/ 10.1016/j.ijpp.2022.05.007
UL DIN S., MAK H.W.L. (2021) Retrieval of land-use/land cover change (LUCC) maps and urban expansion dynamics of Hyderabad, Pakistan via Landsat datasets and support vector machine framework. Remote Sensing, 13(16):3337. https://doi.org/ 10.3390/rs13163337
VIECELI T., TEJADA S., MARTINEZ-REVIEJO R., PUMAROLA T., SCHRENZEL J., WATERER G., RELLO J. (2023) Impact of air pollution on respiratory microbiome: A narrative review. Intensive and Critical Care Nursing, 4(103336). https://doi.org/10.1016/j.iccn.2022.103336
WATSON T., TONG M., BAILIE J., EKANAYAKE K., BAILIE R. (2024) Relationship between climate change and skin cancer and implications for prevention and management: A scoping review. Public Health, 227:243–249. https://doi.org/10.1016/j.puhe.2023.12.003
WICKHAM H. (2016) ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag, New York.
WICKHAM H., FRANÇOIS R., HENRY L., MÜLLER K., VAUGHAN D. (2023) dplyr: A Grammar of data manipu-lation (R package version 1.1.4). https://github.com/tidyverse/dplyr
WICKHAM H., VAUGHAN D., GIRLICH K., USHEY K. (2024) tidyr: Tidy Messy Data. https://cran.r-project.org/web/packages/tidyr/index.html
WORLD DEVELOPMENT INDICATORS (WDI). (2024) World Bank Collection of Development Indicators. The World Bank, Washington DC, United States. https://databa nk.worldbank.org/source/world-development-indicators
YANKOTY L., GAMACHE P., PLANTE C., GOUDREAU S., BLAIS C., PERRON S., FOURNIER M., RAGETTLI M., HATZOPOULOU M., LIU Y., SMARGIASSI A. (2022) Relationships between long-term residential exposure to total environmental noise and stroke incidence. Noise and Health, 24(113):33–39.https://doi.org/10.4103/nah.nah_34_21
YING D., HUIHUI F., BIN Z., SHUCAO Z. (2022) Contribution isolation of LUCC impact on regional PM2.5 air pollution: Implications for sustainable land and environment management. Frontiers in Environmental Science, 10:825732. https://doi:10.3389/fenvs.2022.825732
YUVAL A., YIFAT A., AMICHAI K., MIRYAM K. (2022) Do high-rise buildings influence melanoma? Tall buildings as positive externalities. Cities, 131:104002. https://doi.org/10.1016/j.cities.2022.104002
ZANINI S., RENZI S., LIMONGI A.R., BELLAVITE P., GIOVINAZZO F., BERMANO G. (2021) A review of lifestyle and environment risk factors for pancreatic cancer. European Journal of Cancer, 145:53–70. https://doi,.org/10.1016/j.ejca.2020.11.040
ZENG Y., HE H., WANG X., ZHANG M., AN Z. (2021) Climate and air pollution exposure are associated with thyroid function parameters: A retrospective cross-sectional study. Journal of Endocrinological Investigation, 44(7):1515–1523. https://doi.org/10.1007/s40618-020-01461-9
ZHANG Y., BOGALE D., LI J., HU L., QIU L., XIE Y., ZHOU G., ZHOU Y., DONG G., KNIBBS L., YANG B. (2024) Greenspace and burden of infectious illnesses among children in 49 low- and middle-income countries. Cell Reports Sustainability, 1(8):100150. https://doi.org/10.1016/j.crsus.2024.100150
ZHEN Y., ZHANG X., ZHANG C., GAO Q., DONG J., ZHANG L., LU X., WANG Y. (2023) Effects of climate change and land use/cover changes on carbon sequestration in forest ecosystems in the coastal area of China. Frontiers in Forests and Global Change, 6(1271239). https://doi.org/10.3389/ffgc.2023.1271239
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